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Veljaca et al., 2003

Unlike the large synthetic molecule semaglutide, orforglipron is a small molecule, though both act by mimicking GLP-1

Among hypoglycemic drugs, sulfonylureas secretagogues and glinide secretagogues can increase the risk of skeletal muscle atrophy, metformin may have adverse effects on skeletal muscle mitochondrial function, and sodium-glucose transporter 2 inhibitors (SGLT2i) increase the risk of sarcopenia [13]